Melflufen hydrochloride

Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells .


Cat. No.: EX-A17519A	Purity: >98%

	Chemical structure of Melflufen hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	580	In-stock
250mg	986	In-stock
500mg	1460	In-stock
1g	2080	In-stock

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CAS No.	380449-54-7
Purity	>98%
Formula	C24H31Cl3FN3O3
Mol Weight	534.879
Color	Off-white to light yellow
State	Solid
Solubility	Soluble in DMSO/H2O
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013;19(11):3019-3031. [2].Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016;174(3):397-409. [3].McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52.
CoA	CoA of Melflufen hydrochloride

Smiles:	O=C(OCC)[C@H](CC1=CC=C(F)C=C1)NC([C@H](CC2=CC=C(N(CCCl)CCCl)C=C2)N)=O.[H]Cl


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