MEK Inhibitor II

MEK Inhibitor II is a selectively potent MEK inhibitor, showing little effect on PKC and PKA. Inhibits Raf1 and ERK1, but only at much higher concentrations. MEK Inhibitor II is cell-permeable. MEK Inhibitor II, also referred to as MEKi-2, is an easily absorbed small molecule that hinders the activity of MEK, an enzyme in the MAPK/ERK pathway. It demonstrates potent inhibition against both MEK1 and MEK2, exhibiting IC50 values of 0.3 nM and 0.4 nM, respectively. Moreover, MEK Inhibitor II has been utilized to examine the effects of MEK inhibition on tumor growth in animal models.


Cat. No.: EX-A15138	Purity: >98%

	Chemical structure of MEK Inhibitor II

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	836	In-stock
500mg	1996	In-stock

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CAS No.	623163-52-0
Purity	>98%
Formula	C14H8ClNO4
Mol Weight	289.671
State	Solid
Solubility	soluble in DMSO
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Khraiwesh MH, et al. Antitrypanosomal activities and cytotoxicity of some novel imido-substituted 1,4-naphthoquinone derivatives. Arch Pharm Res. 2012;35(1):27-33.
CoA	CoA of MEK Inhibitor II

Smiles:	O=C1C(Cl)=C(C(=O)C=2C=CC=CC12)N3C(=O)CCC3=O


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