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Product Information:

MD-224

MD-224 is a highly potent small-molecule human murine double minute 2 (MDM2) degrader.

Cat. No.: EX-A3426    Purity: >98%
Chemical
Chemical structure of MD-224


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mg770In-stock
25mg1280In-stock
50mg1800In-stock
100mg3000In-stock


SynonymsMD-224
CAS No.2136247-12-4
Purity>98%
FormulaC48H43Cl2FN6O6
Mol Weight889.796
Statesolid powder
SolubilitySoluble in DMSO, not in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466
CoACoA of MD-224
Smiles:FC1=C(Cl)C=CC=C1[C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[C@H]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O

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