Mcl1-IN-15

Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity.


Cat. No.: EX-A13848	Purity: >98%

	Chemical structure of Mcl1-IN-15

For research only, Do not use for Human!

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CAS No.	518303-27-0
Purity	>98%
Formula	C22H23NO5S2
Mol Weight	445.552
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Abulwerdi FA, et al., 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem. 2014 May 22;57(10):4111-33.
CoA	CoA of Mcl1-IN-15

Smiles:	O=C(O)CSC1=CC(NS(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)=C3C=CC=CC3=C1O


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