MCB-22-174

MCB-22-174 is a deuterated Piezo1 agonist, with an EC50 value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP).


Cat. No.: EX-A12260	Purity: >98%

	Chemical structure of MCB-22-174

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	get quote	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	3058199-58-6
Purity	>98%
Formula	C16H15Cl2N5OS2
Mol Weight	429.365
Color	Off-white to light yellow
State	Solid
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hao R, et al. A Novel Piezo1 Agonist Promoting Mesenchymal Stem Cell Proliferation and Osteogenesis to Attenuate Disuse Osteoporosis. Small Sci. 2024 Jun 30;4(9):2400061.
CoA	CoA of MCB-22-174

Smiles:	S(C(C1=C(Cl)C=CC=C1Cl)[2H])C=2SC(=NN2)C=3C=NC(NC[C@@H](C)O)=CN3


		Search