MC-vc-PAB-PNU-159682

Mal-VC-PAB-DMEA-PNU-159682 (SET0568) is an antibody-drug conjugate (ADC) drug-linker conjugate. Mal-VC-PAB-DMEA-PNU-159682 is generated by conjugating the potent anti-topoisomerase II inhibitor PNU-159682 to the lysosomally cleavable dipeptide Mc-VC-PAB, and exhibits strong antitumor activity. Mal-VC-PAB-DMEA-PNU-159682 can be used to synthesize CD22-targeting ADCs, such as Anti-CD22-NMS249 . Mal-VC-PAB-DMEA-PNU-159682 is also applicable to the research of non-Hodgkin's lymphoma.


Cat. No.: EX-A7294	Purity: >95%

	Chemical structure of MC-vc-PAB-PNU-159682

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	12000
500mg	get quote

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Synonyms	MC-val-cit-PAB-PNU-159682
CAS No.	1178887-17-6
Purity	>95%
Formula	C66H83N9O22
Mol Weight	1354.4124
Color	Orange to red
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>1 year if stored properly
Storage	Powder -20℃ 1 year; In solvent -20℃ 1 month;
Shipping	Ice bag + foam box available upon request. Cold Chain Logistics available upon request

Reference:	[1].Yu SF, et al. A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs. Clinical Cancer Research, 2015, 21(14):3298-3306.
CoA	CoA of MC-vc-PAB-PNU-159682


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