mc-vc-PAB-MMAE
MC-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
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Cat. No.: EX-A1506 | Purity: >98% |
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| Chemical structure of mc-vc-PAB-MMAE |
For research only, Do not use for Human!
Synonyms | VcMMAE |
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Synonyms 2 | MC-Val-Cit-PAB-MMAE |
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CAS No. | 646502-53-6 |
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Purity | >98% |
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Formula | C68H105N11O15 |
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Mol Weight | 1316.626 |
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Appearance | solid powder |
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Solubility | Soluble in DMSO |
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Shelf Life | >2 years if stored properly |
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Storage | Powder -20℃ 2 years; In solvent -20℃ 1 month; |
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Shipping | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
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Reference: | [1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. |
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CoA | CoA of mc-vc-PAB-MMAE |
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Smiles: | CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCC1=CC=C(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)C=CC2=O)C(C)C)C=C1)C(C)C |
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