mc-vc-PAB-MMAE

MC-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).


Cat. No.: EX-A1506	Purity: >98%

	Chemical structure of mc-vc-PAB-MMAE

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1g	1000	In-stock
5g	400	In-stock
10g	6000	In-stock
25g	get quote	In-stock

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Synonyms	VcMMAE
Synonyms 2	MC-Val-Cit-PAB-MMAE
CAS No.	646502-53-6
Purity	>98%
Formula	C68H105N11O15
Mol Weight	1316.626
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.
CoA	CoA of mc-vc-PAB-MMAE

Smiles:	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCC1=CC=C(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)C=CC2=O)C(C)C)C=C1)C(C)C


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