MC-Val-Cit-PAB-carfilzomib

MC-Val-Cit-PAB-carfilzomib iodide is a conjugate of the ADC toxin molecule and the linker. MC-Val-Cit-PAB-carfilzomib iodide is formed by connecting the irreversible proteasome inhibitor Carfilzomib and the ADC linker MC-Val-Cit-PAB.


Cat. No.: EX-A12855	Purity: >98%

	Chemical structure of MC-Val-Cit-PAB-carfilzomib

For research only, Do not use for Human!

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CAS No.	2055896-83-6
Purity	>98%
Formula	C68H96N11O13
Mol Weight	1275.5557
Color	White to off-white
State	Solid
Solubility	DMSO : 230 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, protect from light, stored under nitrogen; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.
CoA	CoA of MC-Val-Cit-PAB-carfilzomib

Smiles:	C([N+]1(CC(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(=O)[C@@]3(C)CO3)CC(C)C)=O)=O)CC(C)C)=O)CCC4=CC=CC=C4)=O)CCOCC1)C5=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN6C(=O)C=CC6=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C5


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