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Product Information:

MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan

MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan (SHR-A1811 Drug-linker) is a agent-linker conjugates for ADC, consisting Exatecan. Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM).

Cat. No.: EX-A12489    Purity: >98%
Chemical
Chemical structure of MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mg550In-stock
25mg1080In-stock
50mg2100In-stock
100mg3520In-stock
250mg6800In-stock
500mg11200In-stock


SynonymsSHR 169106
CAS No.2414254-51-4
Purity>98%
FormulaC55H60FN9O13
Mol Weight1074.1158
ColorWhite to light yellow
StateSolid
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, sealed storage, away from moisture and light; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Ying Hua, et al. Anti-B7H3 antibody-exatecan analog conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020063673[P]. 2020-04-02.

CoACoA of MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan
Smiles:N(C([C@H](OCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(=O)C=CC2=O)=O)=O)=O)=O)=O)C3CC3)=O)[C@@H]4C5=C6C(C=7N(C6)C(=O)C8=C(C7)[C@](CC)(O)C(=O)OC8)=NC=9C5=C(CC4)C(C)=C(F)C9

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