Maytansinoid DM21

DM21 is a next-generation linker-payload that combines a maytansinoid microtubule-disrupting payload with a stable tripeptide linker. DM21 is conjugated with a humanized antibody against ADAM9 to obtain IMGC936.


Cat. No.: EX-A12587	Purity: >98%

	Chemical structure of Maytansinoid DM21

For research only, Do not use for Human!

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Synonyms	DM21
CAS No.	2243689-80-5
Purity	>98%
Formula	C58H83ClN8O16S
Mol Weight	1215.842
Color	White to off-white
State	solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Olga Ab, et al. Abstract 1841: IMGC936, an investigational ADAM9-targeting antibody drug conjugate, is active against patient-derived ADAM9-expressing xenograft models Free. Cancer Res (2021) 81 (13_Supplement): 1841.
CoA	CoA of Maytansinoid DM21

Smiles:	C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCCCCSCNC([C@@H](NC([C@H](NC([C@@H](NC(CCCCCN5C(=O)C=CC5=O)=O)C)=O)C)=O)C)=O)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]


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