MAT2A-IN-22

MAT2A-IN-22 (Compound 29-1) is a BBB-penetrable and orally active MAT2A inhibitor with an IC50 of 4 nM. MAT2A-IN-22 shows selectivity and inhibitory activity against MTAP-deficient cancer cell lines. MAT2A-IN-22 has anti-tumor effects .


Cat. No.: EX-A16561	Purity: >98%

	Chemical structure of MAT2A-IN-22

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2925330-18-1
Purity	>98%
Formula	C18H14F3N3O
Mol Weight	348.337

Reference:	[1].Yang S, et al. Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models. J Med Chem. 2025 Feb 13;68(3):3480-3494.
CoA	CoA of MAT2A-IN-22

Smiles:	O=C1[C@]2(C=3C(C(NC([2H])([2H])[2H])=N1)=CC=C(C(F)(F)F)C3)C=4C(CC2)=NC=CC4


		Search