MAT2A-IN-21

MAT2A-IN-21 (compound 28) is a potent methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 49 nM. MAT2A-IN-21 selectivity inhibits MTAP-deficient cancer cells.


Cat. No.: EX-A13509	Purity: >98%

	Chemical structure of MAT2A-IN-21

For research only, Do not use for Human!

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CAS No.	3062073-94-0
Purity	>98%
Formula	C26H20F2N4O2
Mol Weight	458.4594
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li C, et al. Discovery of 2(1H)-Quinoxalinone Derivatives as Potent and Selective MAT2A Inhibitors for the Treatment of MTAP-Deficient Cancers. J Med Chem. 2025 Jan 6.
CoA	CoA of MAT2A-IN-21

Smiles:	O=C1C(=NC=2C=CC(=CC2N1C3=CC=C(OC(F)F)C=C3)C4CC4)C=5C=CC=6N=CN(C6C5)C


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