background


Product Information:

MAP855

MAP855 is a highly potent, selective, ATP-competitive and orally active MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM). MAP855 shows equipotent inhibition of wild-type and mutant MEK1/2.

Cat. No.: EX-A6334    Purity: >98%
Chemical
Chemical structure of MAP855


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mgget quoteInquire
100mgget quoteInquire
200mgget quoteInquire
500mgget quoteInquire


CAS No.1660107-77-6
Purity>98%
FormulaC28H23ClF2N6O3
Mol Weight564.97
ColorOff-white to light yellow
Statesolid powder
SolubilitySoluble in DMSO 100 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Poddutoori R, et al. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. J Med Chem. 2022;65(5):4350-4366.

[2]. Hegedüs L, Okumus Ö, Livingstone E, et al. Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation. Cancers (Basel). 2021;13(4):829. Published 2021 Feb 16.

CoACoA of MAP855

KEYWORDS: buy MAP855 | MAP855 supplier | purchase | cost | manufacturer | order | distributor | buy 1660107-77-6 | 1660107-77-6 supplier