background


Product Information:

M8891

M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a K of 4.33 nM.

Cat. No.: EX-A4698    Purity: >98%
Chemical
Chemical structure of M8891


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg975Inquire
100mg1550Inquire
250mg2550Inquire


SynonymsM-8891
CAS No.1464842-09-8
Purity>98%
FormulaC20H17F2N3O3
Mol Weight385.3641
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Heinrich T, Seenisamy J, Becker F, Blume B, Bomke J, Dietz M, Eckert U, Friese-Hamim M, Gunera J, Hansen K, Leuthner B, Musil D, Pfalzgraf J, Rohdich F, Siegl C, Spuck D, Wegener A, Zenke FT. Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer. J Med Chem. 2019 Dec 3. doi: 10.1021/acs.jmedchem.9b01070. [Epub ahead of print] PubMed PMID: 31725285.
CoACoA of M8891
Smiles:C1CN(C(=O)[C@]1(C(=O)NCC2=CC(=CC(=C2)F)F)O)C3=CC4=C(C=C3)NC=C4

KEYWORDS: buy M8891 | M8891 supplier | purchase | cost | manufacturer | order | distributor | buy 1464842-09-8 | 1464842-09-8 supplier