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Product Information:

Lys-Nε-SPDB-DM4

Lys-Nε-SPDB-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody agent conjugate (ADC).

Cat. No.: EX-A17041    Purity: >98%
Chemical
Chemical structure of Lys-Nε-SPDB-DM4


For research only, Do not use for Human!

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CAS No.1280215-91-9
Purity>98%
FormulaC48H72ClN5O13S2
Mol Weight1026.694
ColorWhite to off-white
StateSolid
SolubilityDMSO : 50 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture and light; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Hans K Erickson, et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res. 2006 Apr 15;66(8):4426-33.

CoACoA of Lys-Nε-SPDB-DM4
Smiles:C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(NCCCC[C@H](N)C(O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1

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