LYG-409

LYG-409 is an orally active degrader of GSPT1. LYG-409 shows excellent anti-acute myeloid leukemia and prostate cancer in vivo with TGI of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells mediated by the degradation of GSPT1 with an IC50 of 9.50 nM, with a DC50 of 7.87 nM in vitro.


Cat. No.: EX-A12135	Purity: >98%

	Chemical structure of LYG-409

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	765	In-stock
100mg	995	In-stock
250mg	get quote	In-stock
500mg	2400	In-stock
1g	3900	In-stock

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Synonyms	LYG409
CAS No.	3053857-55-6
Purity	>98%
Formula	C25H20F3N3O6
Mol Weight	515.438
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang Y, et al. Design and Discovery of Preclinical Candidate LYG-409 as a Highly Potent and Selective GSPT1 Molecular Glue Degraders. J Med Chem. 2025 Feb 13;68(3):2608-2638.
CoA	CoA of LYG-409

Smiles:	O=C1N(CC2=C1C=CC(CNC(C3=CC4=C(OC3)C=CC(OC(F)(F)F)=C4)=O)=C2)C5CCC(NC5=O)=O


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