LY356318

LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM). LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis .


Cat. No.: EX-A16501	Purity: >98%

	Chemical structure of LY356318

For research only, Do not use for Human!

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Synonyms	LY-356318
CAS No.	1889218-34-1
Purity	>98%
Formula	C23H19F3N10O4
Mol Weight	556.4568
Color	white to light yellow
State	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bamps D, et al. TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde-Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology. Clin Pharmacol Ther. 2023 Nov;114(5):1093-1103. [2]. Broad LM, et al. Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318. Pain. 2025 Apr 18.
CoA	CoA of LY356318

Smiles:	FC(F)(F)C1=NC=C(C=N1)C2=NC(NC([C@@H](N3C4=C(N=C3)N(C(N(C4=O)CC5=NC(C)=NO5)=O)C)C)=O)=CC=C2


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