LY3056480

LY3056480 is a γ-secretase inhibitor. LY3056480 inhibits the Notch signaling pathway, upregulates Atoh1, promotes hair cell regeneration, and drives supporting cell transdifferentiation. LY3056480 is applicable to research related to sensorineural hearing loss.


Cat. No.: EX-A13165	Purity: >98%

	Chemical structure of LY3056480

For research only, Do not use for Human!

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CAS No.	2064292-78-8
Purity	>98%
Formula	C23H28F3N3O4
Mol Weight	467.4813
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Schilder AGM, et al. A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss. Nature communications. 2024 Mar 01;15(1):1896. [2]. Samarajeewa A, et al. Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration. Molecular therapy : the journal of the American Society of Gene Therapy. 2019 May 08;27(5):904-911.
CoA	CoA of LY3056480

Smiles:	COC1=CC2=C([C@@H](C(C=C3N2CCC3(C)C)=O)NC([C@@H](NC(CCC(F)(F)F)=O)C)=O)C=C1


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