LY2801653

Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM) .


Cat. No.: EX-A1264	Purity: >98%

	Chemical structure of LY2801653

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	340	In-stock
250mg	670	In-stock
500mg	1050	In-stock
1g	1700	In-stock
2g	2700	In-stock
3g	3300	In-stock

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CAS No.	1206799-15-6
Purity	>98%
Formula	C30H22F2N6O3
Mol Weight	552.5309
Color	White to yellow
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yan SB, et al. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. Invest New Drugs. 2013 Aug;31(4):833-44. [2].Barat S, et al. Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma. Mol Carcinog. 2016 Jan 12.
CoA	CoA of LY2801653

Smiles:	CN1N=CC2=C1C=C(C1=CNN=C1)C(OC1=CC=C(NC(=O)C3=CC=C(C)N(C3=O)C3=CC=C(F)C=C3)C=C1F)=C2


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