LY2608204

Globalagliatin (LY2608204) is an orally active glucokinase (GK) activator with an EC50 of 42 nM. Globalagliatin also stimulates glucose metabolism in rat insulinoma INS1-E cells with EC50 of 579 nM. Globalagliatin targets both pancreatic β-cells and hepatocytes. Globalagliatin is promising for research of type 2 diabetes.


Cat. No.: EX-A158	Purity: >98%

	Chemical structure of LY2608204

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	1050	In-stock
1g	1650	In-stock
2g	2950	In-stock
5g	6800	In-stock
10g	get quote	Inquire

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CAS No.	1234703-40-2
Purity	>98%
Formula	C28H37N3O3S3
Mol Weight	559.807
Color	white to off-white
State	powder
Solubility	DMSO >50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zheng S, et al. Safety, Pharmacokinetics, and Pharmacodynamics of Globalagliatin, a Glucokinase Activator, in Chinese Patients with Type 2 Diabetes Mellitus: A Randomized, Phase Ib, 28-day Ascending Dose Study. Clin Drug Investig. 2020 Dec;40(12):1155-1166. [2]. Xu M, et al. Unveiling the Influence of a High-Fat Meal on the Pharmacokinetics of Oral Globalagliatin, A Glucokinase Activator, in Healthy Chinese Volunteers. Drugs R D. 2024 Mar;24(1):41-50. [3]. Li P, et al. Clinical investigation of glucokinase activators for the restoration of glucose homeostasis in diabetes. J Diabetes. 2024 May;16(5):e13544.
CoA	CoA of LY2608204

Smiles:	O=C(NC1=NC=C(SCCN2CCCC2)S1)[C@@]1(C[C@H]1C1CCCCC1)C1=CC=C(C=C1)S(=O)(=O)C1CC1


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