LY1

LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PLpro and Mpro with Kd values of 1.5 μM and 2.3 μM for Mpro C145A protein and PLpro C111A protein, respectively. LY1 potent against the viral proteases, with IC50s of 0.12 μM and 0.99 μM against Mpro and PLpro. LY1 shows high selectivity over other kinases, human proteases and metalloenzyme.


Cat. No.: EX-A17061	Purity: >98%

	Chemical structure of LY1

For research only, Do not use for Human!

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Synonyms	5H-Naphth[1,8-cd]isothiazol-5-one, 3-[[2-(1-piperazinyl)phenyl]amino]-, 1,1-dioxide, hydrochloride (1:1)
CAS No.	2883813-32-7
Purity	>98%
Formula	C20H19ClN4O3S
Mol Weight	430.908
Color	Pale purple to purple
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light, stored under nitrogen; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wenying Yu, et al. Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2. J Med Chem. 2022 Dec 22;65(24):16252-16267.
CoA	CoA of LY1

Smiles:	O=C1C=C(C2=NS(=O)(C3=C2C1=CC=C3)=O)NC4=C(C=CC=C4)N5CCNCC5.Cl


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