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Product Information:

LXH254

LXH254 is a potent B/C RAF inhibitor extracted from patent WO2018051306A1, Compound A.

Cat. No.: EX-A1846    Purity: >98%
Chemical
Chemical structure of LXH254


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg617in_stock
250mg1212in_stock
500mg1858in_stock
1g3005in_stock
2g4792in_stock


SynonymsNaporafenib
CAS No.1800398-38-2
Purity>98%
FormulaC25H25F3N4O4
Mol Weight502.4856
ColorOff-white to light yellow
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. CAPONIGRO, Giordano, et al. THERAPEUTIC COMBINATIONS COMPRISING A RAF INHIBITOR AND A ERK INHIBITOR. WO 2018051306 A1 20180322

[2]. Kelli-Ann Monaco, et al. LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors. Clin Cancer Res. 2021 Apr 1;27(7):2061-2073.

CoACoA of LXH254
Smiles:CC1=CC=C(NC(=O)C2=CC(=NC=C2)C(F)(F)F)C=C1C1=CC(OCCO)=NC(=C1)N1CCOCC1

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