LW1564

LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model.


Cat. No.: EX-A12081	Purity: >98%

	Chemical structure of LW1564

For research only, Do not use for Human!

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CAS No.	2668337-39-9
Purity	>98%
Formula	C42H48F3N3O5
Mol Weight	731.8428
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kim I, et al., The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation. Exp Mol Med. 2020 Nov;52(11):1845-1856.
CoA	CoA of LW1564

Smiles:	O=C(N1CCN(CC2=CC=C(C=C2)C(F)(F)F)CC1)COC3=CC=C(C=C3)C45CC6CC(CC(C(=O)N7CC8=CC(OC)=C(OC)C=C8CC7)(C6)C4)C5


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