LRH-1 modulator-1

LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC50 of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10, and reduces the pro-inflammatory cytokines IL-1β and TNFα. LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease.


Cat. No.: EX-A11353	Purity: >98%

	Chemical structure of LRH-1 modulator-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	920	Inquire
25mg	1750	Inquire
50mg	2800	Inquire
100mg	4480	Inquire

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CAS No.	2244781-29-9
Purity	>98%
Formula	C28H36N2O2S
Mol Weight	464.663
Color	Colorless to light yellow
State	Liquid (Density: 1.1
Solubility	DMSO : 66.67 mg/mL
Shelf Life	>3 years if stored properly
Storage	Liquid -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mays SG, et al. Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J Med Chem. 2019;62(24):11022-11034.
CoA	CoA of LRH-1 modulator-1

Smiles:	CCCCCCC1=C([C@@]2(CC[C@@H]([C@@H]2C1)NS(=O)(=O)N)C(=C)C3=CC=CC=C3)C4=CC=CC=C4


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