LOXO-195

Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C.


Cat. No.: EX-A1873	Purity: >98%

	Chemical structure of LOXO-195

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	570	inquire
250mg	778	in_stock
500mg	1102	in_stock
1g	1502	in_stock
5g	5458	in_stock

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Synonyms	LOXO 195
Synonyms 2	Selitrectinib
CAS No.	2097002-61-2
Purity	>98%
Formula	C20H21FN6O
Mol Weight	380.4187
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017, 7(9):963-972.
CoA	CoA of LOXO-195

Smiles:	[H][C@]12CCCN1C1=NC3=C(C=NN3C=C1)C(=O)N[C@H](C)CCC1=NC=C(F)C=C21


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