Loperamide

Loperamide (ADL 2-1294) is selective and orally active μ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2- and Cholera toxin-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea.


Cat. No.: EX-A12370	Purity: >98%

	Chemical structure of Loperamide

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	450	In-stock
250mg	880	In-stock
500mg	1400	In-stock
1g	2250	In-stock
2g	3600	In-stock
3g	4350	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	53179-11-6
Purity	>98%
Formula	C29H33ClN2O2
Mol Weight	477.038
Color	White to off-white
State	solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. DeHaven-Hudkins D L, et al. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity[J]. The Journal of pharmacology and experimental therapeutics, 1999, 289(1): 494-502. [2]. Sandhu BK, et al. Loperamide: studies on its mechanism of action. Gut. 1981;22(8):658-662.
CoA	CoA of Loperamide

Smiles:	O=C(N(C)C)C(C=1C=CC=CC1)(C=2C=CC=CC2)CCN3CCC(O)(C4=CC=C(Cl)C=C4)CC3


		Search