Lolamicin

Lolamicin is an orally effective inhibitor that specifically targets the Gram-negative bacteria lipoprotein transport system LolCDE complex. It selectively inhibits the transmembrane transport of outer membrane lipoproteins by competitively binding to lipoprotein binding sites. Lolamicin destroys the integrity of the bacterial outer membrane, leading to cell death, and has both bactericidal and antibacterial activity. It has significant effects on multidrug-resistant Enterobacteriaceae pathogens (such as Escherichia coli and Klebsiella pneumoniae). Lolamicin can be used to inhibit the study of acute pneumonia, sepsis and other infections caused by Gram-negative bacteria .


Cat. No.: EX-A9599	Purity: >98%

	Chemical structure of Lolamicin

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
50mg	265	In-stock
100mg	465	In-stock

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CAS No.	2930690-12-1
Purity	>98%
Formula	C24H20N4O
Mol Weight	380.4418
Color	off-white to Light yellow
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Muñoz K A, et al. A Gram-negative-selective antibiotic that spares the gut microbiome[J]. Nature, 2024: 1-8.
CoA	CoA of Lolamicin

Smiles:	N#CC1=CC=CC(=C1)COC2=CC=CC(=C2)C3=NNC=C3C4=CC(=NC(=C4)C)C


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