LMTK3-IN-1

LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM.


Cat. No.: EX-A6489	Purity: >98%

	Chemical structure of LMTK3-IN-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	725	In-stock
500mg	925	In-stock
1g	1585	In-stock
2g	2468	In-stock
5g	get quote	In-stock
10g	get quote	In-stock

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Synonyms	LMTK3 inibitor C28
CAS No.	2764850-23-7
Purity	>98%
Formula	C18H11F3N4O
Mol Weight	356.3013
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO 5 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Agnarelli A, et al. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. Int J Mol Sci. 2023 Jan 3;24(1):865. [2]. Ditsiou, Angeliki et al. “The structure-function relationship of oncogenic LMTK3.” Science advances vol. 6,46 eabc3099. 13 Nov. 2020
CoA	CoA of LMTK3-IN-1


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