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Product Information:

LMP744

LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

Cat. No.: EX-A3021    Purity: >98%
Chemical
Chemical structure of LMP744


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg600In-stock
50mg850In-stock
100mg1200In-stock
200mg1800In-stock
500mg2800In-stock
1g4000Inquire


SynonymsMJ-III65
Synonyms 2NSC-706744
CAS No.308246-52-8
Purity>98%
FormulaC24H24N2O7
Mol Weight452.4566
Statesolid powder
SolubilityDMSO : >= 4 mg/mL (9.23 mM)
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30.

[2]. Antony S, et al. Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res. 2007 Nov 1;67(21):10397-405.

CoACoA of LMP744
Smiles:COC1=C(OC)C=C2C(=O)N(CCCNCCO)C3=C(C(=O)C4=CC5=C(OCO5)C=C34)C2=C1

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