LLY-283

LLY-283 is an effective and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) (IC50: 22 nM and a Kd: 6 nM for PRMT5:MEP50 complex). It shows antitumor activity.


Cat. No.: EX-A4936	Purity: >98%

	Chemical structure of LLY-283

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	446	in_stock
250mg	858	in_stock
500mg	1329	in_stock
1g	2155	in_stock

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CAS No.	2040291-27-6
Purity	>98%
Formula	C17H18N4O4
Mol Weight	342.3492
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zahid Q. Bonday, et al. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med. Chem. Lett., 2018, 9 (7), pp 612-617.
CoA	CoA of LLY-283

Smiles:	C1=CC=C(C=C1)[C@H]([C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O)O


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