Linvemastat

Linvemastat (Compound FC-4) is an orally active MMP-12 inhibitor (IC50: < 10  nM) with high selectivity of MMP-1, -2, -3, -7, -9, -10 and -14. Linvemastat significantly attenuates lung fibrosis in Bleomycin induced unilateral lung fibrosis mice model and potently reduces kidney damage, interstitial inflammation or fibrosis in kidney fibrosis model of unilateral ureteral occlusion. Linvemastat can be used for inflammatory diseases research, such as idiopathie pulmonary fibrosis (IPF), inflammatory bowel disease (IBD) and asthma.


Cat. No.: EX-A13612	Purity: >98%

	Chemical structure of Linvemastat

For research only, Do not use for Human!

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CAS No.	2389060-50-6
Purity	>98%
Formula	C20H17N3O4S
Mol Weight	395.432
Color	Off-white to light yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. YANG, W J, et al. Matrix metalloproteinase (mmp) inhibitors and methods of use thereof. WO2019222157A1. 2019-11-21.
CoA	CoA of Linvemastat

Smiles:	O=C1NC(=O)C(N1)C=2OC=CC2SC3=CC=C(OCC=4C=CN=C(C4)C)C=C3


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