Lei-Dab 7

Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a Kd of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels[1][2].


Cat. No.: EX-A15468	Purity: >98%

	Chemical structure of Lei-Dab 7

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1mg	922	in-stock
5mg	get quote	in-stock

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CAS No.	1061556-49-7
Purity	>98%
Formula	C141H236N46O39S6
Mol Weight	3392.057
Color	White to off-white
State	Solid
Solubility	soluble in H2O
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 1 year; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. V G Shakkottai, et al. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51. [2]. Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11. [3]. Bedel Mpari, et al. Small-conductance Ca(2+)-activated K(+) channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers. Eur J Pharmacol. 2008 Jul 28;589(1-3):140-8.
CoA	CoA of Lei-Dab 7

Smiles:	CC[C@H](C)[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC2=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC4=CN=CN4)C(=O)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N


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