LEE011

Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.


Cat. No.: EX-A304	Purity: >98%

	Chemical structure of LEE011

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10g	263	in_stock
25g	531	in_stock
50g	834	in_stock
100g	1321	in_stock

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Synonyms	Ribociclib
CAS No.	1211441-98-3
Purity	>98%
Formula	C23H30N8O
Mol Weight	434.5373
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10. [2]. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.
CoA	CoA of LEE011

Smiles:	CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N1C1CCCC1


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