LDC203974

LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects.


Cat. No.: EX-A5273	Purity: >98%

	Chemical structure of LDC203974

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	785	In-stock
250mg	1250	In-stock
500mg	1850	In-stock
1g	2650	In-stock
5g	get quote	Inquire
10g	get quote	Inquire

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Synonyms	IMT1B
CAS No.	2304621-06-3
Purity	>98%
Formula	C24H21ClFNO6
Mol Weight	473.878
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 200 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nina A Bonekamp, et al. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716.
CoA	CoA of LDC203974

Smiles:	O=C([C@@H]1CN(C([C@H](OC2=CC=C(C(O3)=C2)C(C4=CC=C(F)C=C4Cl)=CC3=O)C)=O)CCC1)O


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