LC-MB12

LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity.


Cat. No.: EX-A8565	Purity: >98%

	Chemical structure of LC-MB12

For research only, Do not use for Human!

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CAS No.	2828438-38-4
Purity	>98%
Formula	C43H44Cl2N10O8
Mol Weight	899.778
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 130 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ma L, et al. Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer. J Med Chem. 2023 Jun 8;66(11):7438-7453.
CoA	CoA of LC-MB12

Smiles:	O=C(N(C)C1=CC(NC2=CC=C(N3CCN(CC3)C(C4CCN(CC4)C5=CC=C6C(N(C7C(NC(CC7)=O)=O)C(C6=C5)=O)=O)=O)C=C2)=NC=N1)NC8=C(Cl)C(OC)=CC(OC)=C8Cl


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