Laropiprant

Laropiprant(MK-0524) is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.


Cat. No.: EX-A2099	Purity: >98%

	Chemical structure of Laropiprant

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	1150	In-stock
1g	1650	In-stock
2g	3000	In-stock
5g	get quote	In-stock

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Synonyms	MK-0524
CAS No.	571170-77-9
Purity	>98%
Formula	C21H19ClFNO4S
Mol Weight	435.896
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Labrecque P, et, al. Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PLoS One. 2013 Jun 10;8(6):e65767. [2]. Sturino CF, et, al. Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J Med Chem. 2007 Feb 22;50(4):794-806. [3]. Chang SW, et, al. The pharmacokinetics and disposition of MK-0524, a Prosglandin D2 Receptor 1 antagonist, in rats, dogs and monkeys. Xenobiotica. 2007 May;37(5):514-33.
CoA	CoA of Laropiprant

Smiles:	CS(=O)(=O)C1=CC(F)=CC2=C1N(CC1=CC=C(Cl)C=C1)C1=C2CC[C@@H]1CC(O)=O


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