L1Au2

TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib-resistant lung cancer.


Cat. No.: EX-A12778	Purity: >98%

	Chemical structure of L1Au2

For research only, Do not use for Human!

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CAS No.	3038386-42-1
Purity	>98%
Formula	C24H25AuClFN6O2P
Mol Weight	711.886
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang L, et al. Dual-Targeting TrxR-EGFR Alkynyl-Au(I) Gefitinib Complex Induces Ferroptosis in Gefitinib-Resistant Lung Cancer via Degradation of GPX4. J Med Chem. 2025 Feb 19.
CoA	CoA of L1Au2

Smiles:	FC1=CC=C(C=C1Cl)NC=2N=CN=C3C=C(OC)C(OCC#[C-][Au+][P]45CN6CN(CN(C6)C4)C5)=CC32


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