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L-(-)-threo-3-Hydroxyaspartic acid

L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].

Cat. No.: EX-A15247    Purity: >98%
Chemical
Chemical structure of L-(-)-threo-3-Hydroxyaspartic acid


For research only, Do not use for Human!

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CAS No.7298-99-9
Purity>98%
FormulaC4H7NO5
Mol Weight149.1021
ColorWhite to off-white
StateSolid
Solubilitysoluble in NaOH
Shelf Life>3 years if stored properly
StoragePowder -20℃, 3 years; In solvent -20℃, 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Hara R, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor A3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54

[2]. Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27.

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