L-371,257

L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM).


Cat. No.: EX-A6940	Purity: >98%

	Chemical structure of L-371,257

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	650	In-stock
100mg	985	In-stock
200mg	1450	In-stock
500mg	2250	In-stock
1g	get quote	In-stock
5g	get quote	Inquire

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CAS No.	162042-44-6
Purity	>98%
Formula	C28H33N3O6
Mol Weight	507.5781
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 8.33 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Williams PD, et al. 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist. J Med Chem. 1995 Nov 10;38(23):4634-6. [2]. Tunstall BJ, et al. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. PLoS Biol. 2019 Apr 16;17(4):e2006421.
CoA	CoA of L-371,257


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