KY-26

KY-26 is a prominent, tri-functional sulfonyl-triazole covalent kinase probe designed for direct target site identification via LC-MS chemical proteomics. Featuring an alkyne handle for click chemistry and a tyrosine-reactive sulfonyl-triazole head, KY-26 serves as an invaluable tool compound for chemical biology research and tyrosine-targeted covalent modification profiling.


Cat. No.: EX-A17579	Purity:

	Chemical structure of KY-26

For research only, Do not use for Human!

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Formula	C33H31N11O4S
Mol Weight	677.736
State	solid
Shelf Life	>3 years if stored properly
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].McCloud RL, Yuan K, Mahoney KE, Bai DL, Shabanowitz J, Ross MM, Hunt DF, Hsu KL. Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25. PMID: 34431655; PMCID: PMC8592385.
CoA	CoA of KY-26

Smiles:	O=S(N1C=NC(C2=CC=CC=C2)=N1)(C3=CC=C(C(N4CCN(CC4)C5=NC(C(NCC#C)=O)=CC(NC6=NNC(C7CC7)=C6)=N5)=O)C=C3)=O


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