KS-58

KS-58 is a KRpep-2d derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-58 can enter cells and block intracellular Ras interaction with effector proteins. KS-58 inhibits the proliferation of tumor cells and has antitumor activity .


Cat. No.: EX-A15770	Purity: >98%

	Chemical structure of KS-58

For research only, Do not use for Human!

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CAS No.	2549046-46-8
Purity	>98%
Formula	C64H89FN12O14S2
Mol Weight	1333.592
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sakamoto K, et al. Nanoformulation of the K-Ras(G12D)-inhibitory peptide KS-58 suppresses colorectal and pancreatic cancer-derived tumors. Sci Rep. 2023 Jan 10;13(1):518. [2]. Sakamoto K, et al Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo. Sci Rep. 2020 Dec 10;10(1):21671.
CoA	CoA of KS-58

Smiles:	C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@]4(N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC5=CC=C(F)C=C5)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCCCC)NC(=O)[C@@]6(CSCCCSC[C@@](NC3=O)(C(=O)NCCC(=O)N7[C@](C(=O)N[C@@H](CCCC)C(=O)N6)(CCC7)[H])[H])[H])CCC4)[H]


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