KRAS G13D-IN-1

KRAS G13D-IN-1 (Compound 41) is a selective and covalently reversible inhibitor of KRASG13D (IC50: 0.41 nM). The selectivity for KRASG13D is 29-fold against KRAS wild type. KRAS G13D-IN-1 is an inhibitor of the GDP state and targets the SWII binding pocket of KRASG13D. KRAS G13D-IN-1 inhibits KRAS binding to GDP and turns on/off downstream signaling cascades. KRAS G13D-IN-1 can be used in the research of colon cancer.


Cat. No.: EX-A12257	Purity: >98%

	Chemical structure of KRAS G13D-IN-1

For research only, Do not use for Human!

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Purity	>98%
Formula	C43H45ClF4N8O2
Mol Weight	817.316
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nilewski C, et al. Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors. ACS Med Chem Lett. 2023 Dec 6;15(1):21-28.
CoA	CoA of KRAS G13D-IN-1

Smiles:	NC1=N[C@@]([C@@]2=C(F)C3=C(C(N4[C@@H](C)CN(C(/C=C/C5=CC=CC6=C5C[N@@]7C[C@H]6CC7)=O)CC4)=NC(OC[C@@]89CCCN8CC(C9)=C)=N3)C=C2Cl)=C(C(F)(F)F)C(C)=C1


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