KMS99220

KMS99220 is an orally active Nrf2 inhibitory protein Keap-1 activator. KMS99220 promotes Nrf2 nuclear translocation, up-regulates the gene expression of antioxidant enzymes (such as heme oxygenase-1, etc.) and proteasome subunits, alleviates oxidative stress and protein aggregation damage. KMS99220 can be used in the research of Parkinson’s disease (PD) .


Cat. No.: EX-A15796	Purity: >98%

	Chemical structure of KMS99220

For research only, Do not use for Human!

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CAS No.	1478585-60-2
Purity	>98%
Formula	C23H25ClF3NO3
Mol Weight	455.898
Color	White to off-white
State	Solid
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lee JA, et al. The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2. Exp Neurobiol. 2018;27(5):408-418. [2]. Lee JA, et al. Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220. Neurochem Int. 2018;112:96-107. [3]. Lee JA, et al. KMS99220 Exerts Anti-Inflammatory Effects, Activates the Nrf2 Signaling and Interferes with IKK, JNK and p38 MAPK via HO-1. Mol Cells. 2019;42(10):702-710.
CoA	CoA of KMS99220

Smiles:	O=C(C1=CC=C(C=C1)OCCCN2CCOCC2)/C=C/C3=C(C=CC=C3)C(F)(F)F.Cl


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