KME-2780

KME-2780 is the orally active inhibitor for IRAK1 and IRAK4 with IC50s of 19 nM and 0.5 nM. KME-2780 can be used for research of dysregulation of innate immune signaling and hematologic malignancies.


Cat. No.: EX-A14045	Purity: >98%

	Chemical structure of KME-2780

For research only, Do not use for Human!

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CAS No.	2968466-26-2
Purity	>98%
Formula	C20H23N5
Mol Weight	333.4301
Color	White to yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, protect from light; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bennett J, et al. Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. Blood. 2023 Sep 14;142(11):989-1007.
CoA	CoA of KME-2780

Smiles:	CC1(CC1)C2=CN3C(C4=CC=CC(N[C@H]5CCNC5)=N4)=CN=C3C=C2


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