KM11060

KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis therapeutics.


Cat. No.: EX-A5067	Purity: >98%

	Chemical structure of KM11060

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	685	In-stock
1g	985	In-stock
5g	3650	In-stock
10g	get quote	In-stock

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CAS No.	774549-97-2
Purity	>98%
Formula	C19H17Cl2N3O2S
Mol Weight	422.328
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89. [2]. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.
CoA	CoA of KM11060

Smiles:	O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C23)CC1)(C4=CC=C(Cl)C=C4)=O


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