Kira8 Hydrochloride

Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM[1].


Cat. No.: EX-A15291	Purity: >98%

	Chemical structure of Kira8 Hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	788	In-stock
100mg	1085	In-stock
250mg	1985	In-stock
500mg	get quote	in-stock
1g	get quote	in-stock

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Synonyms	AMG-18 Hydrochloride
CAS No.	2250019-92-0
Purity	>98%
Formula	C31H30Cl2N6O3S
Mol Weight	637.579
Color	White to yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Morita S, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 4;25(4):883-897.e8.
CoA	CoA of Kira8 Hydrochloride

Smiles:	CC1=C(C2=C(C=C1)C(=CC=C2)NS(=O)(=O)C3=CC=CC=C3Cl)OC4=C(C=CC=N4)C5=NC(=NC=C5)N[C@H]6CCCNC6.Cl


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