KIN001-266

Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM.


Cat. No.: EX-A6263	Purity: >98%

	Chemical structure of KIN001-266

For research only, Do not use for Human!

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100mg	1385	Inquire
200mg	2185	Inquire

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Synonyms	Cot inhibitor-2
CAS No.	915363-56-3
Purity	>98%
Formula	C26H25Cl2FN8
Mol Weight	539.435
Color	Light yellow to green yellow
State	solid powder
Solubility	Soluble in DMSO 40 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.
CoA	CoA of KIN001-266


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