KGA-2727

KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.


Cat. No.: EX-A4089	Purity: >98%

	Chemical structure of KGA-2727

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
500mg	1820	In-stock
1g	2720	In-stock

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CAS No.	666842-36-0
Purity	>98%
Formula	C26H40N4O8
Mol Weight	536.6178
Color	white to off-white
State	powder
Solubility	Soluble in DMSO/Ethanol/H2O
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, protect from light, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Shibazaki T, et al. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96.
CoA	CoA of KGA-2727

Smiles:	O=C(N)CCNCCCOC1=CC=C(CC2=C(C(C)C)NN=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(C)=C1


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