KDM5B-IN-4

KDM5B-IN-4 (compound 11ad) is a lysine demethylase 5B (KDM5B) inhibitor with an IC50 of 0.025 μM KDM5B-IN-4 increases substrate H3K4me1/2/3 level by inhibiting KDM5B in PC-3 cells. KDM5B-IN-4 downregulates PI3K/AKT. KDM5B-IN-4 reduces tumor volume in mice and shows less toxic to organs .


Cat. No.: EX-A17389	Purity: >98%

	Chemical structure of KDM5B-IN-4

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	1085	Inquire
250mg	1685	Inquire

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CAS No.	3046228-11-6
Purity	>98%
Formula	C30H30N6O
Mol Weight	490.5988
Color	White to off-white
State	solid powder
Solubility	DMSO : 33.33 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Cao Y, et al. Discovery of a novel 1H-pyrazole- [3,4-b] pyridine-based lysine demethylase 5B inhibitor with potential anti-prostate cancer activity that perturbs the phosphoinositide 3-kinase/AKT pathway. Eur J Med Chem. 2023 May 5;251:115250.
CoA	CoA of KDM5B-IN-4

Smiles:	CN1CCN(CC1)CCNC(C2=CC(C3=CC=C4C=CC=CC4=C3)=NC5=C2C=NN5C6=CC=CC=C6)=O


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