KB03-SLF

KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF , an FKBP12 ligand that does not support the degradation of FKBP12 NLS. KB03-SLF fails to degrade nuclear-localized FKBP12 NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12 NLS in a manner similar to KB02-SLF .


Cat. No.: EX-A8185A	Purity: >98%

	Chemical structure of KB03-SLF

For research only, Do not use for Human!

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CAS No.	2384184-42-1
Purity	>98%
Formula	C50H63ClF3N5O12
Mol Weight	1018.51

Reference:	[1].Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nature chemical biology. 2019 Jul;15(7):737-746.
CoA	CoA of KB03-SLF

Smiles:	O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCOCCOCCNC(CCNC(C3=CC(C(F)(F)F)=CC(NC(CCl)=O)=C3)=O)=O)=O)=C2)CCC4=CC=C(OC)C(OC)=C4


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